%0 Journal Article
%A Skoglund, Pontus
%A Thompson, Jessica C.
%A Prendergast, Mary E.
%A Mittnik, Alissa
%A Sirak, Kendra
%A Hajdinjak, Mateja
%A Salie, Tasneem
%A Rohland, Nadin
%A Mallick, Swapan
%A Peltzer, Alexander
%A Heinze, Anja
%A Olalde, Iñigo
%A Ferry, Matthew
%A Harney, Eadaoin
%A Michel, Megan
%A Stewardson, Kristin
%A Cerezo-Román, Jessica I.
%A Chiumia, Chrissy
%A Crowther, Alison
%A Gomani-Chindebvu, Elizabeth
%A Gidna, Agness O.
%A Grillo, Katherine M.
%A Helenius, I. Taneli
%A Hellenthal, Garrett
%A Helm, Richard
%A Horton, Mark
%A López, Saioa
%A Mabulla, Audax Z. P.
%A Parkington, John
%A Shipton, Ceri
%A Thomas, Mark G.
%A Tibesasa, Ruth
%A Welling, Menno
%A Hayes, Vanessa M.
%A Kennett, Douglas J.
%A Ramesar, Raj
%A Meyer, Matthias
%A Pääbo, Svante
%A Patterson, Nick
%A Morris, Alan G.
%A Boivin, Nicole
%A Pinhasi, Ron
%A Krause, Johannes
%A Reich, David
%+ Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Advanced DNA Sequencing Techniques, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
The Leipzig School of Human Origins (IMPRS), Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Advanced DNA Sequencing Techniques, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
The Leipzig School of Human Origins (IMPRS), Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society
%T Reconstructing prehistoric African population structure : 
%G eng
%U https://hdl.handle.net/11858/00-001M-0000-002D-F216-A
%R 10.1016/j.cell.2017.08.049
%7 2017-09-21
%D 2017
%* Review method: peer-reviewed
%X Summary<br>We assembled genome-wide data from 16 prehistoric Africans. We show that the anciently divergent lineage that comprises the primary ancestry of the southern African San had a wider distribution in the past, contributing approximately two-thirds of the ancestry of Malawi hunter-gatherers ∼8,100–2,500 years ago and approximately one-third of the ancestry of Tanzanian hunter-gatherers ∼1,400 years ago. We document how the spread of farmers from western Africa involved complete replacement of local hunter-gatherers in some regions, and we track the spread of herders by showing that the population of a ∼3,100-year-old pastoralist from Tanzania contributed ancestry to people from northeastern to southern Africa, including a ∼1,200-year-old southern African pastoralist. The deepest diversifications of African lineages were complex, involving either repeated gene flow among geographically disparate groups or a lineage more deeply diverging than that of the San contributing more to some western African populations than to others. We finally leverage ancient genomes to document episodes of natural selection in southern African populations.<br>PaperClip
%K adaptation, Africa, ancient DNA, hunter-gatherers, natural selection, population genetics, population history
%J Cell
%V 171
%N 1
%& 59
%P 59 - 71.e21
%I Cell Press
%C Cambridge, Mass.
%@ 0092-8674