%0 Journal Article
%A Dannemann, Michael
%A He, Zhisong
%A Heide, Christian
%A Vernot, Benjamin
%A Sidow, Leila
%A Kanton, Sabina
%A Weigert, Anne
%A Treutlein, Barbara
%A Pääbo, Svante
%A Kelso, Janet
%A Camp, J. Gray
%+ The Minerva Research Group for Bioinformatics, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
The Minerva Research Group for Bioinformatics, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
The Leipzig School of Human Origins (IMPRS), Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Modern and Archaic Human Cell Biology, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Single Cell Genomics, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Single Cell Genomics, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
The Minerva Research Group for Bioinformatics, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Modern and Archaic Human Cell Biology, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
%T Human stem cell resources are an inroad to Neandertal DNA functions : 
%G eng
%U https://hdl.handle.net/21.11116/0000-0006-9363-4
%R 10.1016/j.stemcr.2020.05.018
%D 2020
%8 18.06.2020
%* Review method: peer-reviewed
%X Induced pluripotent stem cells (iPSCs) from diverse humans offer the potential to study<br>human functional variation in controlled culture environments. A portion of this variation<br>originates from ancient admixture between modern humans and Neandertals, which<br>introduced alleles that left a phenotypic legacy on individual humans today. Here we<br>show that a large iPSC repository harbors extensive Neandertal DNA, including alleles<br>that contribute to human phenotypes and diseases, encode hundreds of amino acid<br>changes, and alter gene expression in specific tissues. We provide a database of the<br>inferred introgressed Neandertal alleles for each individual iPSC line, together with the<br>annotation of the predicted functional variants. We also show that transcriptomic data<br>from organoids generated from iPSCs can be used to track Neandertal-derived RNA<br>over developmental processes. Human iPSC resources provide an opportunity to<br>experimentally explore Neandertal DNA function and its contribution to present-day<br>phenotypes, and potentially study Neandertal traits.
%K Induced pluripotent stem cells, Neandertal genomics, Cerebral organoids, Archaic introgression, Single-cell transcriptomics
%J Stem Cell Reports
%V 15
%& 214
%P 214 - 225
%I Cell Press
%C Cambridge, Massachusetts
%@ 2213-6711
%U https://www.biorxiv.org/content/10.1101/309658v1.full